姓名:张志军
职称:教授(三级)
个人简介:江苏泰州人,医学博士,博士研究生导师,Duke University 医学中心博士后。
专业研究领域:基础医学、感觉与运动障碍研究、急慢性痛和痒的基础与临床研究。
代表性论文:
1.Qingjian Han, Yong Ho Kim, Xiaoming Wang, et al.SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons[J]. Neuron.
2.Bao-Chun Jiang, De-Li Cao,Xin Zhang, et al.CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5[J].J Clin Invest.
3.Gang Chen, Yong Ho Kim, Hui Li, et al.PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1[J].Nature Neuroscience.
4.Zhi‑Jun Zhang, Jian‑ShuangGuo, Si‑Si Li, et al. TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG[J]. J Exp Med.
5.Zhi-Jun Zhang, Han-Yu Shao, Chuan Liu, et al.Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR+neurons[J]. EMBO reports.
6. Sangsu Bang, Ya-Kai Xie, Zhi-Jun Zhang, et al. GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain[J]. J Clin Invest.
7.Xiao-Bo Wu, Peng-Bo Jing, Zhi-Jun Zhang, et al. Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell[J]. Neuropsychopharmacology.
8.Zhi-Jun Zhang,Bao-Chun Jiang, Yong-Jing Gao. Chemokines in neuron-glial cell interaction and pathogenesisof neuropathic pain[J]. Cell Mol Life Sci.
9. Yan Shen, Zhi-Jun Zhang,Ming-Di Zhu, et al. Exogenous induction of HO-1 alleviates vincristine-induced neuropathic pain by reducing spinal glial activation in mice[J]. Neurobiol Dis.
10.Zhi-Jun Zhang, De-Li Cao, Xin Zhang, et al.Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR
11.Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, et al. Chemokine CCL2 and its receptor CCR
12. Alexander Chamessian, Megumi Matsuda, Michael Young, et al. Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury[J]?Journal of Neuroscience.
13.Bao-Chun Jiang, Wen-Wen Zhang, Tian Yang, et al. Demethylation of G-Protein-Coupled Receptor 151 Promoter Facilitates the Binding of Krüppel-Like Factor 5 and Enhances Neuropathic Pain after Nerve Injury in Mice[J]. Journal of Neuroscience.
14.Bao-Chun Jiang, Li-Na He,Xiao-Bo Wu,et al.Promoted Interaction of C/EBPа with Demethylated Cxcr3Gene Promoter Contributes to Neuropathic Pain in Mice[J].Journal of Neuroscience.
15.De-Li Cao, Bin Qian, Zhi-Jun Zhang, et al.Chemokine receptor CXCR
16. Qian Zhang, De-Li Cao, Zhi-Jun Zhang, et al.Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice[J]. Journal of Neuroinflammation.
17.Chun-Ling Huang, Lu-Lu Sun, Chen-Yang Xiao, et al. Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1[J]. Journal of Neuroinflammation.
18. Xiao-Xia Fang, Meng-Nan Zhai, Meixuan Zhu,et al. Inflammation in pathogenesis of chronic pain: Foe and friend[J]. Molecular Pain.
19. Jing Zhu, Fei Huang, Yonglin Hu , Wei Qiao , Yingchao Guan, Zhi-Jun Zhang#, Su Liu, Ying Liu. Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation[J]. J Inflamm Res.
20.Xiao-Xia Fang, Heng Wang, Hao-Lin Song, et al. Neuroinflammation Involved in Diabetes-Related Pain and Itch[J]. Frontiers in Pharmacology.
21.Yuan-Yuan Fu, Jian-Ke Cen, Hao-Lin Song, et al. Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis[J]. Molecular Pain.
22.Zi-Han Wu, Han-Yu Shao, Yuan-Yuan Fu, et al. Descending Modulation of Spinal Itch Transmission by Primary Somatosensory Cortex[J]. Neurosci Bull.
23. Lin-Xia Zhao, Ming Jiang, Xue-Qiang Bai, et al.TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice[J].Neurosci Bull.
24.Huan-Jun Lu, Yuan-Yuan Fu, Qian-Qi Wei, Zhi-Jun Zhang. Neuroinflammation in HIV-Related Neuropathic Pain[J]. Frontiers in Pharmacology.
25.Xiao-Ming Liu, Zhi-Jun Zhang, Zhu-Qiang Cheng, et al.Spinal Heme Oxygenase-1 (HO-1) Exerts Antinociceptive Effects Against Neuropathic Pain in a Mouse Model of L5 Spinal Nerve Ligation[J]. Pain Med.
26.Bin Qian, Feng Li, Lin-Xia Zhao, et al.Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund’s Adjuvant Peripheral Injection[J]. Cell MolNeurobiol.
27.Zhi-Jun Zhang, Peng-Bo Jing, Yong-Jing Gao.Microinjection of Virus into Lumbar Enlargement of Spinal Dorsal Horn in Mice[J]. Bio-Protocol.
28.Ying Lu, Bao-Chun Jiang, De-Li Cao, et al. TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling[J]. Pain.
29.De-Li Cao, Zhi-Jun Zhang, Rou-Gang Xie, et al.Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2[J]. Exp Neurol.
30.Jie Hui, Zhi-Jun Zhang, Xin Zhang, et al. Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord[J]. J Pain.
31.Jian-ShuangGuo, Peng-Bo Jing, Ji-An Wang, et al.Increased autophagic activity in dorsal root ganglion attenuates neuropathic pain following peripheral nerve injury[J]. Neurosci Lett.
32.Ming-Di Zhu, Lin-Xia Zhao, Xiao-Tian Wang,et al.Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain[J].Brain Res Bull.
33.Zhi-Jun Zhang, Lin-Xia Zhao, De-Li Cao, et al. Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells[J]. Cell MolNeurobiol.
34.Bao-Chun Jiang, Wen-Xing Sun, Li-Na He, et al.Identification of lncRNA expression profile in the spinal cord of mice following spinal nerve ligation-induced neuropathic pain[J]. Molecular Pain.
35.Feng-Li Chen, Yu-Lin Dong, Zhi-Jun Zhang, et al. Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model[J]. Brain Res Bull.
36.Xu-Hua Ge, Guo-Ji Zhu, De-Qin Geng, et al.Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3β-mediated mitochondrial translocation of Bax in PC12 cells[J]. Neurol Sci.
主要科研项目
主持多项省部级以上科研项目,其中包括国家自然科学基金面上项目2项和江苏省自然科学基金面上项目1项。另参与和指导多项省部级以上科研项目,具体如下:
1.国家自然科学基金,面上项目,2020-01-01至2023-12-31,主持;
2.国家自然科学基金,面上项目,2016-01-01至2019-12-31,主持;
3.江苏省自然科学基金,面上项目,2019-07至2022-06,主持;
4.国家自然科学基金,面上项目,2019-01-01至2022-12-31,参与(第二);
5.国家自然科学基金,面上项目,2014-01-01至2017-12-31,参加(第二);
6.国家自然科学基金,面上项目,2012-01-01至2015-12-31,参加(第二);
7.江苏省自然科学基金,面上项目,2010-09-01至2013-12-31,参加(第二);
8. 国家级大学生创新创业训练计划项目,2014-05至2016-04,指导老师;
9.国家级大学生创新创业训练计划项目,2019-05至2020-04,指导老师;
10.国家级大学生创新创业训练计划项目,2018-05至2020-04,指导老师;
11.国家级大学生创新创业训练计划项目,2022-05至2024-04,指导老师。
人才工程
1. 江苏省“333”高层次人才;
2. 江苏省高校中青年学术带头人;
3. 江苏省高校优秀青年骨干教师;
4. 南通市“226”高层次人才;
5. 国家级优秀教学团队骨干成员(人体解剖学);
6. 国家精品课程骨干成员(人体解剖学);
7. 第三批国家级精品资源共享课骨干成员;
8. 江苏省高校优秀科技创新团队骨干成员。
教学科研获奖
1. 教育部科学研究优秀成果二等奖,2019年;
2. 江苏省科学技术三等奖,2019年;
3. 江苏医学科技三等奖,2020年;
4. 江苏省高等学校科学技术研究成果二等奖,2016年;
5.华东地区青年学者高峰论坛一等奖,2017年;
6. 第八届全国大学生基础医学创新论坛大赛,金奖和最佳学术奖,2023年;
7.第四届全国大学生基础医学创新论坛大赛,二等奖,2016年;
8.南通市第九届自然科学优秀学术论文二等奖,2015年;
9.中国解剖学会第五届解剖学微课竞赛三等奖,2021年;
10.澳门永利集团3044第二届全英文教学讲课竞赛二等奖,2014年。
荣誉称号
1.澳门永利集团3044优秀教育工作者,2019年;
2.第八届全国大学生基础医学创新论坛大赛,优秀指导教师,2023年;
3. 澳门永利集团3044创新训练项目优秀指导教师,2016年。
专利申请
授权发明专利一项(中国专利号ZL202010486130.6),授权实用新型专利三项(中国专利号分别是ZL201820912915.3、ZL201820930791.1、ZL202220067627.9)。
会议报告
1.第三届动物实验操作技术国际讲习班,特邀主讲小鼠脊髓和DRG显微注射新技术,主办:同济大学东方转化医学研究中心;
2.动物实验操作技术及实验动物病理诊断高级研修班,特邀主讲小鼠神经系统解剖与手术操作,主办:湖南省实验动物学会;
3.第二届动物实验操作技术国际讲习班,特邀主讲小鼠神经注射技术,主办:同济大学东方转化医学研究中心;
4.华东地区解剖与组织胚胎学青年教师高峰论坛会议,大会报告“背根神经节中TLR8调节神经病理性疼痛的机制研究”,主办:浙江省解剖学会;
5.“和学堂”系列论坛,主讲神经系统病毒载体注射技术,主办:上海和元生物技术有限公司;
6. 国际神经再生高峰论坛-INRS Webinar Series,特邀主讲病毒注射的脑立体定位技术,主办:Neural Regeneration Research(NRR)中国神经再生研究杂志英文版。
学术/社会兼职
中国神经科学会神经胶质细胞分会委员;
中国生理学会疼痛转化研究专业委员会委员;
中国实验动物学会神经科学技术专业委员会委员;
江苏省医学会疼痛学分会青年委员会委员;
江苏省泰州市苏陈镇双岸社区新时代文明实践中心辅导老师;
教育部学位中心论文评审专家;
国家自然科学基金项目的评审专家。
编写教材
《Perry实验小鼠实用解剖》,副主编,北京大学出版社;
《医学动物实验科学》,编委,科学出版社;
《疼痛医学精要》,译者,北京大学医学出版社;
《人体解剖学》,编委,科学出版社;
《神经病学彩色图谱》,译者,上海科学技术出版社。
讲授课程
本科生课程包括:系统解剖学、局部解剖学、五官解剖学、PBL教学、解剖科学进展;硕士生课程包括:人体解剖学与进展、神经解剖学;博士生课程:神经生物学;留学生本科课程包括:Human Anatomy、Regional Anatomy;留学生硕士课程:Sectional Anatomy。
指导研究生情况
已毕业硕士生7名;在读博士生1名、硕士生3名;指导的硕士研究生获得过澳门永利集团3044优秀学位论文、澳门永利集团3044优秀毕业研究生、江苏省研究生神经科学学术创新论坛三等奖、江苏省研究生生命科学学术创新论坛三等奖等荣誉和奖项。