姓名：陈浩
职称：教授
个人简介：博士，江苏省“双创人才”高校创新类。
专业研究领域：基础医学、精子发生与成熟的调控机制。
专著与论集：
1. Jianwu Shi, Kin Lam Fok, Pengyuan Dai, Feng Qiao, Mengya Zhang, Huage Liu, Mengmeng Sang, Mei Ye, Yang Liu, Yiwen Zhou, Chengniu Wang, Fei Sun*, Gangcai Xie*, Hao Chen*. Spatio temporal landscape of mouse epididymal cells and specific mitochondria rich segments defined by large scale single cell RNA seq. Cell Discovery, 7, 34 (2021).
2. Shi J, Qiao F, Ye M, Jiang T, Liu J, Zhang M, Xie G, Fok KL, Li X, Chen H .CSE1L/CAS regulates cell proliferation through CDK signalling in mouse spermatogenesis. Cell Proliferation. 2022 Nov;55(11):e13334.
3. Ye M, Chen Y, Liu J, Tian J, Wang X, Fok KL, Shi J*, Chen H*. Interfering with CSE1L/CAS inhibits tumour growth via C3 in triple-negative breast cancer. Cell Proliferation. 2022 May;55(5):e13226.
4. Li X, Yuan C, Shi J, Kang H, Chen Y, Duan Y, Jin J, Cheung LP, Li TC, Liu Y, Cui Y, Ruan YC, Jiang X, Cai Z, Chan HC, Ji L, Zeng X*, Liu J*, Chen H*, Fok KL*. Beta-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility. Cell Reports Medicine. 2022 Dec 20;3(12):100825.
5. Choy KHK, Chan SY, Lam W, Jin J, Zheng T, Law TYS, Yu SS, Wang W, Li L, Xie G, Yim HCH, Chen H*, FokEKL*. The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis. BMC Biology. 2022 Mar 29;20(1):78.
6. Jin J, Li X, Ye M, Qiao F, Chen H*, Fok KL*. Defb19 regulates the migration of germ cell and is involved in male fertility. Cell and Bioscience. 2022 Nov 22;12(1):188.
7. Shi JW, Zhou YW, Chen YF, Ye M, QiaoF, Tian JW, Zhang MY, Lin HC, Xie GC, Fok KL, Jiang H, Liu Y*, Chen H*. Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation. Asian Journal of Andrology. 2022 May 6. doi: 10.4103/aja202226.
8. Wang C, Zhang J, Fok KL, Tsang LL, Ye M, Liu J, Li F, Zhao AZ, Chan HC, Chen H*. CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis. American Journal of Pathology, 2018 Apr 6. pii: S0002-9440(17)30969-0.
9. Chen H*, Shi X, Li X, Diao R, Ma Q, Jin J, QiuZ, Li C, Yu MK, Wang C, Li X, Li F, Chan DYL, Zhao AZ, Cai Z, Sun F, Fok KL*. CD147 deficiency is associated with impaired sperm motility/acrosome reaction and offers a therapeutic target for asthenozoospermia. Molecular Therapy-Nucleic Acids. 2021 Nov 10;26:1374-1386.
10. Ding N, Zhang X, Zhang XD, Jing J, Liu SS, Mu YP, Peng LL, Yan YJ, Xiao GM, Bi XY, Chen H*, Li FH*, Yao B*, Zhao AZ*. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes. Gut. 2020 Jan 2. pii: gutjnl-2019-319127.
11. Diao R#, Fok KL#, Chen H#, Yu MK, Duan YG, Chung CM, Li Z, Wu HW, Zhang H, Ji ZL, Zhen WH, Ng CF, Gui Y, Cai Z*, Chan HC*. Defective human β-defensin-1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine, 2014,6, 249ra108.
主要科研项目
主持国家重点研发计划课题1项，国家重点研发计划子课题1项，国家自然科学基金项目3项等多项省部级以上科研项目。
讲授课程
解剖学研究进展，生殖生物学及其进展，生理科学研究进展
指导研究生情况
已毕业硕士生5名；在读博士生4名，硕士生7名。